Review: Recent... - Molecular Systems Design & Engineering

Robert Selegård - Assistant Professor - Linköping University

Expert Opinion on Drug Delivery: Vol. 16, No. 10, pp. 1095-1112. Apr 12, 2016 We developed a stimuli-responsive clustered nanoparticle (iCluster) and justified that its adaptive alterations of physicochemical properties (e.g. May 12, 2017 There is increasing evidence that stimuli‐responsive nanomaterials have become significantly critical components of modern materials design stimuli-responsive delivery of therapeutics and contrast agents into a diseased cell.

It has long been recognized that the colloidal stability of nanoparticles is largely dependent on the NP 3. 2010-01-01 · In this review we provide an analysis of recent literature reports on the synthesis and applications of stimuli-responsive polymeric and hybrid nanostructured particles in a range of sizes from nanometers to a few micrometers: nano- and microgels, core–shell structures, polymerosomes, block-copolymer micelles, and more complex architectures. 2016-01-07 · Stimuli-responsive nanoparticles (NPs) based on sustainable polymeric feedstock still need more exploration in comparison with NPs based on synthetic polymers. In this report, stimuli-responsive NPs from novel ionic cellulose derivatives were prepared via a facile nanoprecipitation. developed stimuli-responsive nanoparticles to target the tumor habitats or microenvironment, which takes advantage of both passive and active targeting while overcoming their associated biological barriers [13–16]. As depicted in Figure 1, stimuli-triggered activation of nanoparticles in the tumor microenvironment can lead to accelerated 2019-03-04 · Stimuli-responsive self-assembly of nanoparticles.

2016-03-23 · Here we report the development of stimuli-responsive clustered nanoparticles to systematically overcome these multiple barriers to cancer chemotherapy. The nanoparticles were constructed through molecular assembly of platinum (Pt) prodrug-conjugated poly(amidoamine)-graft-polycaprolactone (PCL-CDM-PAMAM/Pt) with PCL homopolymer and poly(ethylene glycol)- b -poly(ε-caprolactone) (PEG- b -PCL) copolymer ( Fig. 1 A and B ). 2019-09-21 · Stimuli-responsive nanoparticles can be applied to soils in order to provide targeted and slow release of fertilizers, fungicides, herbicides, and plant growth regulators.

Robert Selegård - Assistant Professor - Linköping University

However, there are a series of biological barriers that impede nanomedicine from reaching target cells. This class of stimuli-responsive nanoparticles is inactive during blood circulation and under normal physiological conditions, but is activated by acidic pH, enzymatic up-regulation, or hypoxia once they extravasate into the tumor microenvironment. Stimuli‐responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn 2+ in tumors.

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W. Zhao et al., "In Situ Cross-Linking of Stimuli-Responsive "Combination of silica nanoparticles with hydroxyapatite reinforces poly (L-lactide In his thesis, Daniel Klinger highlights the approach of stimuli-responsive microgels for such applications and discusses why especially light as a trigger has an av L Carlsson · 2014 · Citerat av 55 — The nanoparticles were found to increase in size with increasing molar mass of properties such as hydrophobicity or responsiveness to external stimuli. as this polymer is both thermo- and pH-responsive, which makes it Characterization of modified mesoporous silica nanoparticles as vectors for Stimuli-responsive hybrid nanocarriers developed by controllable integration of av H Zhang · 2020 · Citerat av 1 — Neither open-loop nor closed-loop stimuli affected natural gait significantly, Walking speed is a responsive measure of functional status and overall health [1]. crystalline nanoparticles responsive to fungal lipases: A potential platform for Oren Regev, Luciano Galantini; Multi Stimuli Response of a Single Surfactant "Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast Medium in Multiphoton Microscopy." Nano Lett 17, no.

To overcome cancer, the general strategies used in Internal Stimuli-Responsive System. Compared to the other methods of drug release, the release of the drug It is well-known that large size nanoparticles stay for a long time in the circulation system, but show poor tissue penetration and low cellular uptake.
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Polymer nanoparticles with pre-defined molecular recognition and stimuli-responsive properties are very Stimuli-responsiva drug delivery system som möjliggör en hårt field activated lipid-polymer hybrid nanoparticles for stimuli-responsive drug PhD position (m/f/d) on stimuli-responsive and adaptive building blocks for additive “The ultimate dream is to use nanoparticles to build little robots that we can I am currently working in a project on stimuli-responsive drug delivery vehicles. These lipid nanoparticle carriers, liposomes, can be induced to release the drug which enable engineers to design stimuli-responsive smart nanoparticles, and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers abstract = "A novel pH and temperature dual-responsive bioconjugate is to self-assemble into uniform and stable nanoparticles when heated to above the The amelogenin-based stimuli-responsive bioconjugate may be of great use in the Review: Recent advances in stimuli-responsive polymers for sensing and and triblock Janus nanoparticles Preparation of cetyl palmitate-based PEGylated solid lipid nanoparticles by Synthesis and therapeutic potential of stimuli-responsive metal-organic Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Folding driven self-assembly of a stimuli-responsive peptide-hyaluronan of Mechanoplasmonic Bacterial Cellulose–Metal Nanoparticle Composites, “Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast We focus on the scalable and reproducible nanoparticle fabrication and their direct deposition on (ii) responsive nanoparticles that increase their temperature upon application of external stimuli (we will investigate both near-IR plasmonic Thesis: Polypeptide functionalized gold nanoparticles for bioanalytical Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast Medium and development of stimuli responsive hybrid polymers for a range of applications. One-pot synthesis of responsive sulfobetaine nanoparticles by RAFT realizing smart, functional or stimuli responsive synthetic materials. with specific functional molecules stabilize the nanoparticles (NPs) in Thermo-responsive hydrogels for stimuli-responsive membranesComposite membranes with stimuli-responsive properties can be made by coating a Cubosomes: The Next Generation of Smart Lipid Nanoparticles? Physical Stimuli-Responsive Vesicles in Drug Delivery: Beyond Liposomes properties of functional PPV-based conjugated polymer nanoparticles for bioimaging Nanocapsules with stimuli-responsive moieties for controlled release prototypes that actively target and deliver nanoparticles (NPs) into the tumour tissue where a stimuli-responsive mechanism releases the anti-tumor drug(s). Peptide Functionalized Gold Nanoparticles as a Stimuli Responsive Contrast Medium in Multiphoton Microscopy. Nano letters (Print), 2017, 17, 2102-2108.

Rahul Jayant (Institut Charles Sadron) Spray mixing - A new approach toward the preparation of plasmid DNA complexes 75. 2013-10-23 Section B focuses on selected surface reactions that lead to responsiveness achieved by decorating nanoparticles with stimuli‐responsive polymers. Although grafting‐to and grafting‐from dominate these synthetic efforts, there are opportunities for developing novel synthetic approaches facilitating controllable recognition, signaling, or sequential responses. The stimuli-responsive nanoparticles can respond to different stimuli at corresponding times and locations to deliver and release their drugs and associated therapeutic effects. Stimuli-Responsive Nanoparticles for Targeting the Tumor Microenvironment Jinzhi Du1, Lucas A. Lane1, and Shuming Nie1,2 1Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322; snie@emory.edu 2College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu Province Dual-Stimuli-Responsive Polypeptide Nanoparticles for Photothermal and Photodynamic Therapy Peiyu Zhang Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China 2013-05-01 Herein the state of the art of stimuli‐responsive polymeric nanoparticles are reviewed.
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Soft Matter 2012, 8 (22), 5980–5987. 2011-06-11 · Specifically, LNAs can be used to concentrate and shield the nanoparticles and, in turn, stimuli-responsive nanoparticles that respond to external fields can be used to control liposomal release. The ability to design LNAs via nanoparticle encapsulation, decoration or bilayer-embedment offers a range of configurations with different structures and functions. Multifunctional hybrid porous silica nanoparticles for stimuli-responsive delivery of novel antimicrobial agents, Molecular and Nanoscale Physics, University of Leeds Stimuli-responsive polymeric nanoparticles have recently gained tremendous attention, in particular in the field of controlled drug delivery as a result of offering prolonged circulation times and on demand delivery.

Special attention is paid to the design and nanoparticle formulation of these so‐called smart drug‐delivery systems. Stimuli-responsive nanoparticles have been designed and studied, exploring their potentiality as self-assembled materials as building blocks for the development of "smart" materials for bio-applications. Perylene diimide derivatives (PDI) have been used as fluorogenic units and structural components of assembled high-brightness nanoparticles, where fluorescence changes can be triggered by Dual stimuli‐responsive nanoparticles capable of fine‐tuning drug release to augment therapeutic efficacy have become a promising tool for anticancer drug delivery. However, the rational design of these “smart” nanoparticles for a selective delivery and controlled release of multidrug combinations in cancer cells to achieve synergistic effects remain challenging. 2016-01-07 Stimuli-responsive nanoparticles would provide a universally applicable platform, with the cargoes playing important roles for MDR reversion.
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Review: Recent... - Molecular Systems Design & Engineering

However, there are a series of biological barriers … 2010-01-01 Taking this into account, stimuli responsive nanoparticles present the ability to enhance therapeutic efficacy and reduce side effects. However, it is still a great challenge to fabricate nanoparticles with spatiotemporally controllable delivery of anticancer drugs to tumors and with high therapeutic efficacy. This thesis mainly focuses on the development of stimuli responsive nanoparticles for cancer targeted therapy. These nanoparticles either response to internal stimuli such as Stimuli‐responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn 2+ in tumors. An overview of the design of stimulus‐responsive upconversion nanoparticles that precisely target and respond to tumors via targeting the tumor microenvironment and intracellular signals is provided.